Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms
GJM Webster, S Reignat, MK Maini, SA Whalley… - Hepatology, 2000 - Elsevier
After hepatitis B virus (HBV) infection, liver injury and viral control have been thought to
result from lysis of infected hepatocytes by virus-specific cytotoxic T cells. Patients are
usually studied only after developing significant liver injury, and so the viral and immune
events during the incubation phase of disease have not been defined. During a single-
source outbreak of HBV infection, we identified patients before the onset of symptomatic
hepatitis. The dynamics of HBV replication, liver injury, and HBV-specific CD8+ and CD4+ …
result from lysis of infected hepatocytes by virus-specific cytotoxic T cells. Patients are
usually studied only after developing significant liver injury, and so the viral and immune
events during the incubation phase of disease have not been defined. During a single-
source outbreak of HBV infection, we identified patients before the onset of symptomatic
hepatitis. The dynamics of HBV replication, liver injury, and HBV-specific CD8+ and CD4+ …